Recent Posts


SAMe (S-Adenosyl Methionine): Why and How to Use?

Tuesday, September 7, 2021

SAMe S-adenosyl methionine is an important option in the treatment of many diseases, from depression to fibromyalgia. What exactly does SAMe do? How is it used?

I know you’ve heard a lot about SAMe S-adenosyl methionine. I have a lot to share about this supplement that I use a lot in the clinic.

Because, although there is nutritional support on paper, SAMe’s effects are serious enough to be evaluated in the “medicine” category. So I’m sure that the well-known SAMe will make people happy with the disease.

That is why I will share many details from the definition of SAMe, usage, effects, dosage range you are curious about.

What is SAMe?

Methionine, an amino acid, and ATP which is used as a source of energy in the body; This substance, known as S-adenosyl methionine, S-adenosyl L-methionine or SAMe, is very important. This is because it is a methyl donor and is more or less effective than other methyl donors.

Methyl donor protects cells from major problems such as cancer and aging because it reduces damage to important structures. So if you have more methyl donors in your body, you will be better protected.

That SAMe is a methyl donor means taking part in many chemical reactions in the body and maintaining the metabolic functions. When you think that you are involved in more than 100 chemical reactions, you will realize how important SAMe is.

I know you’re curious about the details. Let’s move on!

When can SAMe be used?

There are five different uses identified and approved for S-adenosyl methionine. I will share these points with you. But I want you to know that new ones will be added to the fields listed below because the research is continuing.


SAMe is necessary for the construction of conducting elements such as phosphotidyl choline and phosphotidyl serine in the brain. Therefore, it allows many neurological functions to continue.

At the same time, research shows that the levels of serotonin associated with depression increase with the use of SAMe, and that cell-to-cell activity increases.

Some studies have even shown that SAMe is more effective and well tolerated than tricyclic antidepressant drugs that are commonly used in severe cases such as major depression.

Other studies have suggested that SAMe may be a potential therapeutic tool in many situations, such as reducing symptoms of schizophrenia, and correcting postpartum depressive symptoms.

But unfortunately, this data is still in its infancy. There are also big question marks about the use in schizophrenia. Therefore, it is useful to be careful.


Osteoarthritis, which is commonly known as calcification and is caused by damage to the articular cartilage, is an important disease that seriously affects quality of life and movement.

Depression is okay, but what does SAMe have to do with calcification?

This discovery actually comes from the improvement in osteoarthritis symptoms of individuals during research on depression.

When the research continued SAMe;
Slows joint destruction by reducing inflammation,
Accelerates the production of proteoglycan for joint repair,
It acts as a painkiller to relieve the person.

These data are invaluable because we can clearly see that SAMe can continue the treatment with a restorative and analgesic effect without any side effects such as painkillers.

Liver diseases

Increased toxic substances, malnutrition and other problems increased the risk of liver disease. With the increase in the frequency and severity of the disease, sometimes the natural and chemical treatment tools are not sufficient.

At this point, I want to talk about some of the effects that can be used in liver diseases. Research shows that SAMe,

Reduce mortality and / or liver transplantation rate in individuals with cirrhosis,
It may decrease liver enzyme height due to toxic factors,
It can improve the process when used in addition to medical treatment in cholestasis, which is a condition of inhibition of bile flow.
As a result, SAMe can be evaluated in addition to treatment in complex liver diseases.

I’d like to share a nice animal experiment.

Use of SAMe in mice exposed to liver cancer chemicals can reduce the risk of cancer. This data shows that SAMe can be used experimentally in individuals who are at risk of liver cancer, particularly those receiving chemotherapy.

I share this with my patients in the clinic and I am taking my options according to the situation.


There are many different approaches to fibromyalgia, one of the boring diseases in the dark whose origins have not been investigated.

The main approach is to stop the pain, get rid of the patient.

Unfortunately, this doesn’t work. Because no painkillers for fibromyalgia are useless when you don’t get to the origin of the event.

To illustrate this to my patients, I give an example of a set of landslides. Because no set can prevent landslides. The real solution is to tighten the soil!

In fibromyalgia, SAMe is another agent that helps to reduce inflammation and to support the process. He not only helps to increase the level of glutathione, but also reduces the pain by increasing the level of seratonin.

Considerations when using SAMe

The first rule is of course physician approval. As with any other support, consult your physician before using SAMe. If everything is OK and SAMe is recommended, I recommend you to pay attention to the following points.

Avoid the use of SAMe in bipolar, schizophrenia, Parkinson’s disease and pregnancy.

Some findings related to folate deficiency may disappear with the use of SAMe. In this case, never stop using folic acid.

Do not take SAMe with antidepressants or 5-HTP. Although it seems safe, we have no clear evidence.

Also do not take SAMe if you are using a drug containing dextromethorphan active substance. To understand the seriousness, dextromethorphan even exists in cough syrups, which are described as simple!

Dosage recommendation

I prescribe SAMe for a wide range of doses for my patients. So I will not have a clear proposal. But I prepared a simple table for you to understand the situation.

Disease           Minimum Dose           Maximum Dose
Depression                800 mg            1,200 mg
Osteoarthritis            400 mg            1,200 mg
Liver disease             800 mg            1.200 mg
Fibromyalgia             800 mg            1,000 mg

Now you know a lot about S-adenosyl methionine (SAMe). I hope we can find SAMe in our country soon. Because now we can only provide SAMe from abroad so that I can provide SAMe to my patients.

Also don’t forget to share your comments and comments with me!

Ten Foods to Help You Relieve Your Arthritis Pain

Food is medicine. If you are struggling with pain caused by arthritis; Eating foods with antioxidant, anti-inflammatory and pain-relieving p...